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Epanova (omega-3-carboxylic acids) : ウィキペディア英語版 | Epanova (omega-3-carboxylic acids)
Epanova is an FDA approved prescription medication used alongside a low fat and low cholesterol diet that lowers high triglyceride (fat) levels in adults. Epanova is the third prescription formulation of omega-3 polyunsaturated fatty acid approved in the United States but the first in free fatty acid form. It is derived from fish oil and an ultra pure mixture of the free fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). The drug contains a concentration of DHA at 15-25 % and a concentration of EPA at 50-60%. The active ingredient of Epanova is a mixture of these free fatty acids derived from crude marine fish oil – a natural occurring substance. Compared to other prescription omega-3s medications, Epanova has a dosing option as few as two capsules once a day. AstraZeneca, the company that developed Epanova, is commercializing the drug in the United States as a prescription monotherapy for patients with severe hypertriglyceridemia, and researching the safety and efficacy of combination therapy using Epanova and statins for patients with mixed dyslipidemia.〔 == Medical Uses == Epanova has been shown to be effective in treating hypertriglyceridemia. Approximately 4 million American adults have hypertriglyceridemia, a condition where fat accumulates in the blood. More specifically, these patients have high levels of triglycerides, fats carried in the blood with lipoproteins, above 200 mg/dL leading to an increased risk of cardiovascular disease. The disease stems from both genetic and environmental factors including obesity, high-caloric diet and a sedentary lifestyle. The prevalence of hypertriglyceridemia is rapidly increasing across the United States and throughout the world. A National Health and Nutrition Examination Survey suggests that the “percentage of patients with severe hypertriglyceridemia has risen sharply along with the dramatic increases in obesity.”
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